Triamino pyrimidines and pyridines as histamine H4 receptor modulators
Bioorganic & Medicinal Chemistry Letters(2011)
摘要
Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure–activity relationships evaluated for activity at the H4 receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.
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关键词
Pyrimidine,Pyridine,Histamine,Histamine H4,Antagonist
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