ChemInform Abstract: The Design and Synthesis of Novel Adenosine Agonists.

P. J. SCAMMELLS, S. P. BAKER,L. BELLARDINELLI, R. A. OLSSON, R. A. RUSSELL, S. A. KNEVITT

Cheminform（2010）

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摘要

Abstract The 2R and 2S-endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1 adenosine receptor. The 2S-endo isomer was equipotent to N6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.

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nucleic acids

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