Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice.

Denis Angoulvant,Shafie Fazel,Richard D Weisel,Teresa Y Y Lai,Paul W Fedak,Liwen Chen, Shahin Rafati,Charit K Seneviratne,Norbert Degousee,Ren-Ke Li

The Journal of Thoracic and Cardiovascular Surgery（2009）

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摘要

Tissue inhibitor of matrix metalloproteinase-3 overexpression enhanced the effects of bone marrow stromal cells transplanted early after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice by contributing regulated matrix metalloproteinase inhibition to preserve matrix collagen and improve functional recovery.

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关键词

ADAM,ANOVA,BMSC,ECM,ELISA,FAC,LV,MI,MMP,TIMP,timp3−/−,TNF-α,TUNEL,VEGF

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