Synthesis and antibacterial activity of 2-alkoxy penems.

A Afonso,F Hon,N Fett,J Weinstein,A K Ganguly,L Naples,R S Hare,G H Miller

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkyltlhiopenems 2. (C) 1998 Elsevier Science Ltd. All rights reserved.

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