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Antigen-dependent leukotriene synthesis and histamine release from IgG1 passively-sensitized guinea pig lungs ex vivo: Relationship between serum levels of antigen-specific IgG1 and mediator synthesis/release

Pulmonary Pharmacology, no. 4 (1990): 171-179

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Abstract

Naive guinea-pigs were passively sensitized with varying amounts of affinity column purified, homologous, anti-ovalbumin IgG1 (anti-OA IgG1) and then examined for a) the capacity of lung tissue to release mediators (histamine and LTB4LTD4) in response to antigen-challenge ex vivo and b) the attendant circulating levels of anti-OA IgG1. In...More

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