A Practical Synthesis of “Metabolite A₁” (AAMU) of Caffeine

D. Gala,D. DiBenedetto,F. Günter,M. Kugelman,D. Maloney,M. Cordero,I. Mergelsberg

ORGANIC PROCESS RESEARCH & DEVELOPMENT（1997）

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摘要

A three-pot, preparative scale synthesis of 5-acetamido-6-amino-3-methyluracil, "metabolite A(1)" (AAMU) (2) of caffeine, from readily available 6-aminouracil (3) in 72% overall yield is described.

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A Practical Synthesis of “Metabolite A1” (AAMU) of Caffeine

A Practical Synthesis of “Metabolite A₁” (AAMU) of Caffeine