Exchange of serine residues 263 and 266 reduces the function of mouse gap junction protein connexin31 and exhibits a dominant-negative effect on the wild-type protein in HeLa cells.
Experimental Cell Research（2004）
摘要
To characterize the role of Cx31 phosphorylation, serine residues 263 and 266 (Cx31Δ263,266) or 266 (Cx31Δ266) alone were exchanged for amino acids that cannot be phosphorylated.
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关键词
Intercellular communication,Carboxyterminal phosphorylation,Protein trafficking,Dominant-negative effect,Heteromeric channels
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