Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Discovery of a stable and soluble Bcl-xl inhibitor derived from kendomycin has been disclosed.

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关键词

Kendomycin,Bcl-2, Bcl-xl,Apoptotic,Semi-synthetic,High-throughput screening,Ketal

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