Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

Zehong Wan,Hongxing Yan,Ralph F. Hall,Xichen Lin,Stefano Livia,Tomasz Respondek,Katherine L. Widdowson,Chongjie Zhu,James F. Callahan

Tetrahedron Letters（2009）

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摘要

Chemoselectivity of chlorine versus methylthio (–SCH3), methylsulfinyl (–SOCH3), or methylsulfonyl [–S(O)2CH3] in either functionalization or substitution of pyridopyrimidinone and pyrimidopyrimidinone was studied. Utilization to prepare final targets for accelerated SAR studies via two-dimensional array syntheses has been demonstrated in both systems.

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