A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells.

Elodie Viry,Eric Battaglia,Valérie Deborde,Tobias Müller,Régis Réau,Elisabeth Davioud-Charvet,Denyse Bagrel

CHEMMEDCHEM（2008）

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摘要

A phosphine-coordinated gold(I) thiosugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF-7 cells.

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关键词

antitumor agents,gold,inhibitors,oxidoreductases,thioredoxin reductase

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