Endometrial levels of amikacin in the mare after intrauterine infusion of amikacin sulfate

Amikacin sulfate, e e Bristol Veterinary Products, P.O. Box 657, Syracuse, New York 13201 a semi-synthetic aminoglycoside antibiotic derived from kanamycin, is a broad spectrum antibiotic particularly effective against gram-negative organisms. With this spectrum of activity, amikacin may be an effective treatment for equine metritis. The purpose of this study was to determine the level of amikacin in the endometrium after intrauterine infusion. For three consecutive days, four mares were infused with 2.0 gms once a day and four others were infused with 3.0 gms once a day. Biopsy results indicate that amikacin is readily absorbed into the equine endometrium. The 3.0 gm dose appears to have no therapeutic advantage over the 2.0 gm dose. Amikacin could not be detected in the serum after intrauterine infusion.