Selenium level is associated with apoE ε4 in rural elderly Chinese

Objective: Se is in essential trace element in human nutrition associated with antioxidant activity. Previous studies oil predictors of toenail Se or serum Se have mostly concentrated oil demographic factors such as age and gender. The present paper examines the association between apoE genotype and Se levels in nail samples in a rural elderly Chinese cohort. Design: Two thousand Chinese aged 65 years and over from four counties in China were enrolled ill a cohort to study the association of Se with cognitive decline. Nail samples were collected from each participant and analysed for Se levels. Dietary Se intake was estimated from an FFQ using Se contents measured in food items collected from each village. Blood samples oil filter cards were collected and analysed for apoE genotype. Mixed-effect models were constructed with nail Se level as the dependent variable and each village as the random effect, which controlled for the potential confounding effect from correlation ill Se measures obtained from participants residing in the same village. Results: in this elderly Chinese cohort, carriers of the apoE epsilon 4 allele had significantly lower Se levels measured in nail samples than non-carriers after adjusting for other significant covariates and controlling for estimated dietary Se intake. There was no significant difference between the two genotypes oil estimated Se dietary intake (P=0.6451). Conclusions: Future studies are needed to examine the mechanism underlying the association between the a aPoE epsilon 4 allele and Se levels, including the role of oxidative stress and that of reduced lipid metabolism in the apoE epsilon 4 carriers.