Dioxolane cytosine nucleosides as anti-hepatitis B agents
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1995)
摘要
In order to study the structure-activity relationships, several dioxolane pyrimidine nucleosides have been synthesized and their anti-HBV activities have been evaluated in 2.2.15 cells. From the study it was found that 5-fluoro-cytosine derivatives exhibited the most potent anti-HBV activity.
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关键词
structure activity relationship
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