Substituted Biaryl Oxazoles, Imidazoles, and Thiazoles As Sodium Channel Blockers
Bioorganic & medicinal chemistry letters(2010)
摘要
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low molecular weight biaryl substituted imidazoles, oxazoles, and thiazole carboxamides were identified with good in vitro and in vivo potency.
更多查看译文
关键词
Neuropathic pain,Voltage-gated sodium channel,Na(v)1.7 blockers,Biaryl oxazoles,Biaryl imidazoles,Biaryl thiazoles
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要