Samarium(II)-Mediated 4-exo-trig Cyclization. A Stereocontrolled Approach to the Core of Pestalotiopsin A
ORGANIC LETTERS(2001)
摘要
Pestalotiopsin A is a structurally unique caryophyllene-type sesquiterpene which has shown immunosuppressive activity and cytotoxicity in preliminary assays. A stereocontrolled approach to the functionalized 2-oxabicyclo[3.2.0]heptane core of pestalotiopsin A is described. The approach includes a samarium(II)-mediated 4-exo-trig cyclization and a trans-lactonization process triggered by the addition of alkylytterbium reagents to a cyclobutanone intermediate.
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关键词
crystal structure
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