Endogenous tumour necrosis factor-alpha sensitise melanoma cells to glucosaminylmuramyl dipeptide

Tatyana I Valyakina,Ravilya L Komaleva,Elena E Petrova,Alexander A Malakhov,Ol'ga G Shamborant,Tatyana M Andronova,Vladimir A Nesmeyanov

FEBS Letters（1998）

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摘要

Flow cytometry was used to demonstrate that cultured human melanoma BRO cells expressed membrane-bound tumour necrosis factor-alpha (TNF-α) and were able to release TNF-α upon treatment with glucosaminylmuramyl dipeptide (GMDP). The released TNF-α was shown to prime melanoma cells, previously unable to respond to GMDP by increasing expression of melanoma-associated antigens, making them sensitive to GMDP treatment.

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关键词

Tumour necrosis factor,Muramyl peptide,Melanoma-associated antigen

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