A facile preparation of (2,4,6-14C)-cyanuric acid under solvent-free conditions

(2,4,6-C-14)-Cyanuric acid was prepared from C-14-urea by the heterocyclization of the latter in the presence of ammonium chloride. This procedure involves solvent-free fusing of the reactants in a vacuum sealed glass tube. The product was purified by ion-exchange column chromatography using Sephadex SE C-25. A radiochemical yield of 60.5% was obtained based on C-14-urea and the product had a specific activity of 19.06 mCi/mmol. Copyright (C) 2002 John Wiley Sons, Ltd.