Family 4 Glycosidases Carry Out Efficient Hydrolysis of Thioglycosides by an α,β-Elimination Mechanism
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2006)
摘要
Thioglycosides are widely used as competitive inhibitors of glycosidases. The first glycosidase capable of hydrolyzing unactivated thioglycosides—BglT, a 6-phospho-β-glucosidase from glucosidase family 4—has been found. The efficient cleavage of the thioglycosidic linkage is a consequence of the α,β-elimination mechanism used by GH4 enzymes, in contrast to the nucleophilic displacement mechanisms of “classical” glycosidases.
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关键词
elimination,enzyme catalysis,glycoside hydrolase,thioether cleavage,thioglycosides
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