Inhibition Of Stromelysin-1 (Mmp-3) By Peptidyl Phosphinic Acids

Joung L. Goulet,Joanne F. Kinneary,Philippe L. Durette,Ross L. Stein,Richard K. Harrison,Maria Izquierdo-Martin,David W. Kuo,Tsau-Yen Lin,William K. Hagmann

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1994）

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摘要

A series of phosphinic acid-containing peptide inhibitors of human stromelysin-1 (MMP-3) were prepared. The P1 through P3 subsites were varied in a systematic manner on analogs possessing an invariant P1'-P3' segment. The in vitro activity of these compounds as inhibitors of stromelysin and collagenase is discussed.

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