The search for a hair-growth stimulant: new radicicol analogues as WNT-5A expression inhibitors from Pochonia chlamydosporia var. chlamydosporia
Tetrahedron Letters(2009)
摘要
WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. While searching for an inhibitor of WNT-5A expression, we identified an active compound, radicicol (1), and isolated four unique analogues, pochonins G–J (2–5), from a culture broth of the fungus Pochonia chlamydosporia TF-0480. Structural elucidation of 2–5 and their biological activities against WNT-5A are described.
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关键词
glycoprotein,structure elucidation,biological activity
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