Researchs of etiological surveillance of hand-foot-mouth disease in Wuhua County

Objective To investigate the etiological characteristics and variation of hand-foot-mouth disease(HFMD)in Wuhua county.Methods The stool samples of HFMD cases in sentinel surveillance hospitals were collected in Wuhua county from 2010 to 2012.The total EV,EV71 and CoxA16 nucleic acid were examined by real-time fluorescence quantitative PCR.Results The 125 stool samples were collected,115 cases were positive for EV with the positive rate of75.66%.The difference of EV positive rates between different year were not statistically significant(P0.05).The positive rates of EV71,CoxA16 and other enterovirus were 23.03%,18.42% and 34.21%,respectively,showing statistically significant difference(P0.01).The epidemic strain was EV71 in 2010,and other enterovirus was epidemic in 2011 and 2012,there were not statistically significant difference between different gender and different age(P 0.05).EV71,CoxA16 and other enteroviruses alternately change throughout the year.Conclusion The epidemic strain of HFMD had dynamically changed in Wuhua county.The etiological surveillance of HFMD be strengthened,for grasping the prevalent rule of strain and making control and preventive measures.