Application of hygromycin a structure activity relationships to the antibiotic A201A.

Replacement of the disaccharide portion of A201A with an allyl ether, with concomitant 3-hydroxylation, affords an analog with biological activity comparable to that of the natural product. The response of biological activity to this modification closely parallels that observed with hygromycin A, which implies that these two natural products may share a common binding site.