Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

Dihydropyrazole amides such as 24 are potent inhibitors of KSP with favorable physical properties, pharmacokinetics, and in vivo potency. A diastereoselective synthesis of 24 is described.

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关键词

Cancer,Kinesin spindle protein,KSP inhibitors,Antimitotics,Dihydropyrazoles,P-Glycoprotein

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