Selective Non Zinc Binding Inhibitors of MMP13

Chris De Savi,Andrew D. Morley,Attilla Ting,Ian Nash,Kostas Karabelas,Christine M. Wood,Michael James,Stephen J. Norris,Galith Karoutchi,Neil Rankine,Gordon Hamlin,Philip A. MacFaul,David Ryan,Sarah V. Baker,David Hargreaves,Stefan Gerhardt

Bioorganic & medicinal chemistry letters（2011）

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摘要

Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.

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关键词

MMP13,Selectivity,Non zinc binder,Lead Generation

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