Execution of the replica exchangemolecular dynamics simulator on the Grid

†,††† Replica-exchange method is considered to be suitable for execution on the Grid environment because of its large granurality and small size data transfer. To confirm the suitability, we have performed several experiments on various environment, using an application program called REMD Toolkit that implements Replica-exchange method. But, REMD Toolkit has a probrem to which the the performance falls remarkably on the Grid environment, because it includes the barrier synchronization to all workers. We improve the REMD Toolkit to cope with performance-heterogeneous environment. The results showed that the improved version is faster than original version in the performance-heterogeneous environment.