Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.

Richard Chesworth,Michael P Zawistoski,Bruce A Lefker,Kimberly O Cameron,Robert F Day,F Michael Mangano,Robert L Rosati,Stacy Colella,Donna N Petersen,Amy Brault,Bihong Lu,Lydia C Pan,Pia Perry,Oicheng Ng,Tessa A Castleberry,Thomas A Owen,Thomas A Brown,David D Thompson,Paul DaSilva-Jardine

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER α and ER β selective analogs.

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关键词

Tetrahydroisoquinolines,ER α,ER β

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