Challenges in Implementing a Successful Newborn Cystic Fibrosis Screening Program

Objective To identify necessary components of a successful cystic fibrosis (CF) newborn screening (NBS) program. Study design The approach to CF NBS used by the Massachusetts NBS program was examined. Results Several key components were identified that should be addressed when a state has made the decision to screen, kind well in advance of actual implementation. These components include (1) inclusion of CF center directors in the development process; (2) logistics of choosing a screening algorithm relative to practices in place and community wishes; (3) projections of medical service needs from specific algorithms; (4) identification of critical reporting components; (5) identification of critical follow-up components; and (6) recognition of educational needs. Conclusions Careful examination of a wide variety of issues is needed to ensure optimal implementation of NBS for CF.