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Apoptosis of naive CD4+ T-cells from HIV-infected patients with poor immune response to HAART is enhanced in vitro by steroid.

Pierre-Marie Roger,Isabelle Perbost,Michel Ticchioni,Jean-Gabriel Fuzibet,Jean-Philippe Breittmayer,Jacques Durant,Alain Pesce,Alain Bernard,Pierre Dellamonica, for the Groupe d'Etudes Niçois Polyvalent en Infectiologie (GENPI)

Journal of Infection（2004）

Cited 2|Views15
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Abstract
Objective. Because the absence of immune restoration in HIV-infected patients efficiently treated by highly active antiretroviral therapy (HAART) may be due to excessive immune activation, we prospectively studied the effect of hydrocortisone on T-cell apoptosis in a cohort of patients with satisfactory virologic response.
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Key words
HAART,Immune reconstitution,Apoptosis,Steroid
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