Hyperresponsiveness Of Granulocytes To Anaphylatoxins, C5a And C3a, In Churg-Strauss-Syndrome

T Tanaka,M Abe,T Mitsuyama,Y Fukuoka,T Sakurada,N Hara

INTERNAL MEDICINE（1995）

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摘要

A 50-year-old man with Churg-Strauss syndrome showed granulocytes (GNLs) which generated more superoxide anion (O-2(-)) than GNLs from healthy subjects following in vitro stimulation with C5a or C3a. Production of O-2(-) subsided as the clinical symptoms improved with steroid treatment. A hyperresponsiveness of GNLs may be involved in this disorder.

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关键词

ANAPHYLATOXINS, CHURG-STRAUSS SYNDROME, SUPEROXIDE ANION, EOSINOPHILIA, GRANULOCYTE, COMPLEMENT

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