Effects Recombinant Human Brain Natriuretic Peptide on ventricular fumction and future ventricular remodeling in patients with anterior wall acute myocardial infarction and heart failure

【Objective】To evaluate the influence of recombinant human brain natriuretic peptide(rhBNP) on ventricular function and future ventricular remodeling(LVR) in patients who undergone anterior wall acute myocardial infarction(AMI) and acute heart failure treated with percutaneous coronary intervention(PCI)【.Methods】60 patients with acute anterior myocardial infarction and heart failure for the first time were randomly divided into rhBNP group and the control group,and each 30 cases.The improvement of cardiac function,difficulty breathing,the overall clinical condition and urine were compared between the two groups at 24h after treatment.The NT-proBNP level was measured at baseline and 24h,48h after baseline.The plasma rennin,angiotensin II and aldosterone were measured at baseline and 48h after baseline.The echocardiogram was performed at 24h after drug infusion,discharge and after discharge 6th months,to observe the improvement of cardiac function and future ventricular remodeling.【Results】There were significant differences of the dyspnea,urine output,urine output and intake difference,EF,Tei index between the rhBNP group and the control group at 24h after treatment(P 0.05).Compared with control group,rhBNP group showed a more decrease of the plasma NT-proBNP,rennin,angiotensin II and aldosterone at 48h after treatment(P 0.05).The LVEDV had no significant difference between the two groups,while the EF and Tei index were more increase in rhBNP group.At 6th months after discharge,the EF and Tei index were still higher than the control group(P 0.05),while the rhBNP group showed a more decrease of the LVEDV and △LVEDV%(P 0.05)【.Conclusion】rhBNP can improve the dyspnea and clinical conditions of the patients with heart failure after AMI and can further inhibit the remodeling of left ventricular and improve the left ventricular function.