Realization of features of immune response by dynamical system models and a possible mechanism of memory of antigen invasion
msra(2006)
摘要
Among features of real immune responses which occur when antigens invade a
body,there are two remarkable features. One is that the amount of antibodies
produced in the secondary invasion by the same antigens is more than 10 times
larger than that in the primary invasion. The other is that more effective
antibodies which can neutralize the antigens more quickly are produced by
somatic hypermutation during the immune response. This phenomenon is named as
'affinity maturation'. In this paper, we try to reproduce these features by
dynamical system models and present possible factors to realize them. Further,
we present a model in which the memory of the invasion by antigens is realized
without immune memory cells.
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关键词
dynamic system,somatic hypermutation,immune response
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