N-(Aryl)-4-(azolylethyl)thiazole-5-carboxamides: Novel potent inhibitors of VEGF receptors I and II
Bioorganic & Medicinal Chemistry Letters(2006)
摘要
Novel potent derivatives of 4-(azolylethyl)thiazole-5-carboxamides are described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity reaching IC50<100nM in both enzymatic and cell-based phosphorylation assays. The compounds also inhibit the related tyrosine kinase, VEGFR-1, with similar potencies.
更多查看译文
关键词
Vascular endothelial growth factor receptor 2,Receptor tyrosine kinase,Dual kinase inhibitor,Angiogenesis,4-(Azolylethyl)thiazole-5-carboxamides
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要