Breast cancer metastasis suppressor 1: Update
Clinical & Experimental Metastasis(2003)
摘要
This article reviews information related to the BRMS1 (BReast Metastasis Suppressor 1) metastasis suppressor gene. BRMS1 was identified by differential display comparing metastasis-suppressed chromosome 11 hybrids with metastatic, parental MDA-MB-435 human breast carcinoma cells. BRMS1 has subsequently been shown to suppress metastasis, but not tumorigenicity of human melanoma cells. The murine version, Brms1, also suppresses metastasis and exhibits a high level of homology to the human gene at the structure, nucleotide and amino acid levels. The mechanisms of action remain to be determined; however, BRMS1 transfectant cells have restored gap junctional intercellular communication. Recent data suggest that BRMS1 is part of the mSin3A histone deacetylase complex.
更多查看译文
关键词
breast cancer,BRMS1,melanoma,metastasis suppressor gene,gap junctional intercellular communication
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要