protection of isolated human atrial muscle against simulated ischaemia

Objective: Adenosine receptor activation has been implicated in the mechanism of ischaemic preconditioning protection. Evidence suggests adenosine A receptor involvement, and possibly A receptor involvement in the rabbit. This study investigated the roles of 13 these receptors in human preconditioning. Human A - and A -selective compounds were chosen based on K values for inhibition of 13 i 6 w 125 x . 125 . N - 4-amino-3- I iodobenzyl adenosine I-ABA binding to stably expressed recombinant human A and A receptors. Cyclopenty-