The production of pulmonary oedema in mice by cyclophosphamide and iodide

Mice given 400–450 mg/kg cyclophosphamide (a 30-day LD50) and 500 mg/kg potassium or sodium iodide (30-day LD50) died within a few hours with marked pulmonary oedema and pleural effusions. Among halides this effect was restricted to iodides, and among alkylating agents it was restricted to cyclophosphamide, and was not shared even by the close analogues isophosphamide or trophosphamide.