Nucleophilic Ring Opening of 3-Benzyl-1,3-oxazinanes by Reformatsky Reagents. A Synthesis of Β-Amino Ester Derivatives

A ALBEROLA,MA ALVAREZ,C ANDRES,A GONZALEZ,R PEDROSA

Synthesis（1990）

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摘要

2-Substituted 3-benzyl-1,3-oxazinanes react with the Reformatsky reagent derived from ethyl 2-bromoacetate and zinc, using very mild conditions (0°C, 1h) leading regioselectively to 3-substituted ethyl 3-[(3-hydroxypropyl)benzylamino] propanoates in high yield.

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