Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: Molecular docking analysis and pharmacological studies

Vittoria Colotta,Francesca Capelli,Ombretta Lenzi,Daniela Catarzi,Flavia Varano,Daniela Poli,Fabrizio Vincenzi,Katia Varani,Pier Andrea Borea,Diego Dal Ben,Rosaria Volpini,Gloria Cristalli,Guido Filacchioni

Bioorganic & Medicinal Chemistry（2009）

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摘要

Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series. Molecular docking analysis and pharmacological studies

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关键词

G protein-coupled receptors,Adenosine receptor antagonists,Pyrazoloquinolines,Tricyclic heteroaromatic systems,Ligand–receptor modeling studies

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