Susceptibility To Type 1 Diabetes In The Senegalese Population Is Linked To Hla-Dq And Not Tap And Lmp Genes

OBJECTIVE - To investigate the frequency of the transporter associated with antigen processing (TAP) and large multifunctional protease (LMP) alleles and their role in the susceptibility to type 1 diabetes, in comparison with the well-known HLA-DQ alleles susceptibility, in Senegalese subjects.RESEARCH DESIGN AND METHODS - Three loci in the TAP/LMP region were analyzed in 92 type 1 diabetic subjects and 117 nondiabetic control subjects by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).RESULTS - No association was found between the studied polymorphisms of TAP1, TAP2, and LMP2 and type I diabetes in the Senegalese population, in contrast to the HLA-DQA1 and DQB1 genes, which were associated with type 1 diabetes.CONCLUSIONS - Diabetogenic genes in the class II HLA region are located near the DQA1 and DQB1 loci rather than the TAP and LMP loci.