PI3-kinase is essential for ADP-stimulated integrin α<sub>IIb</sub>β<sub>3</sub>-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin α<sub>IIb</sub>β<sub>3</sub>-initiated signaling cross-talks

Journal of Biomedical Science, Volume 12, Issue 6, 2005, Pages 937-948.

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Keywords:
adpphosphatidylinositol 3-kinasecalcium oscillationp2y receptorsintegrin aiibb3

Abstract:

Summary  Phosphatidylinositol 3-kinase (PI3K) pathway is important for platelet activation. Recent studies showed that PI3K and oscillative calcium could cross talk to each other and positively regulate integrin α IIbβ3-mediated outside-in signaling. However, the mechanism of this feedback regulation remains to be further characterized. ...More

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