Discovery of novel orally active ureido NPY Y5 receptor antagonists.

Guoqing Li,Andrew W Stamford,Ying Huang,Kuo-Chi Cheng,John Cook,Constance Farley,Jun Gao,Lorraine Ghibaudi,William J Greenlee,Mario Guzzi,Margaret van Heek,Joyce J Hwa,Joe Kelly,Deborra Mullins,Eric M Parker,Sam Wainhaus,Xiaoping Zhang

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Structure–activity relationship studies leading to the potent, selective NPY Y5 receptor antagonist 21c are described. Compound 21c demonstrated dose-dependent anti-obesity effects in diet-induced obese rats after chronic oral administration.

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关键词

Neuropeptide Y,NPY Y5 antagonist,Obesity

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