GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a

Jason E. Imbriglio,Sookhee Chang,Rui Liang,Subharekha Raghavan,Darby Schmidt,Abby Smenton,Scott Tria,Thomas O. Schrader,Jae-Kyu Jung,Craig Esser,Tom G. Holt,Michael S. Wolff,Andrew K.P. Taggart,Kang Cheng,Ester Carballo-Jane,M. Gerard Waters,James R. Tata,Steven L. Colletti

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.

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关键词

Niacin,GPR109a,Agonists

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