Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

James Kempson,William J Pitts,Joseph Barbosa,Junqing Guo,Omonike Omotoso,Andrew Watson,Karen Stebbins,Gary C Starling,John H Dodd,Joel C Barrish,Raymond Felix,Karl Fischer

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead. The synthesis, structure–activity relationships (SAR) and selectivity against several other PDE family members are described.

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关键词

PDE7,Pyrimidine

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