Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation.

Ondřej Hovorka,Vladimír Subr,David Větvička,Lubomír Kovář,Jiří Strohalm,Martin Strohalm,Aleš Benda,Martin Hof,Karel Ulbrich,Blanka Ríhová

European Journal of Pharmaceutics and Biopharmaceutics（2010）

引用 39|浏览22

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摘要

Spectral or temporal unmixing allows us to separate fluorescence of doxorubicin from signal emitted by its degradation by-product 7,8-dehydro-9, 10-desacetyldoxorubicinone.

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关键词

Dox,D*,FLIM,HPMA,AOBS,SPAD,TTTR mode,TCSPC

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