A general synthesis of 8-hydroxy-6-substituted-1,7-naphthyridines

Xinglong Jiang,Guang-Pei Chen,Kapa Prasad,Oljan Repič,Thomas J. Blacklock

JOURNAL OF HETEROCYCLIC CHEMISTRY（2007）

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摘要

A general method for the synthesis of 8-hydroxy-6-substituted-1,7-naphthyridines is described using acylation of the dianion derived from tert-butylamide 1, followed by cyclization of the resulting intermediate ketones 2 with ammonium acetate.

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