Anti-malarial activity of N6-modified purine analogues.

Herein we report the synthesis, in vitro and in vivo biological evaluation for a series of purine analogues as anti-malarial agents. N6-hydroxyadenine (1c), 2-amino-N6-aminoadenosine (2b) and 2-amino-N6-amino-N6-methyladenosine (4b) displayed the most promising activity and were found to be non-toxic.