Prokaryotic Recombinant Hemagglutinin-Neuraminidase Protein Enhances the Humoral Response and Efficacy of Commercial Newcastle Disease Vaccines in Chickens

Important Findings The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays an important role in the pathogenesis of Newcastle disease (ND). Recombinant HN (rHN) protein has been used to elicit immunity against NDV in chickens. The data indicated that inclusion of rHN protein produced by an economical prokaryotic expression system could enhance the immunogenicity of traditional and multivalent inactivated ND vaccines. This approach may be adapted to improve the efficacy of ND vaccines currently used in the poultry industry.