5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.

Hiroo Koyama,Julia K Boueres,Wei Han,Edward J Metzger,Jeffrey P Bergman,Dominick F Gratale,Daniel J Miller,Richard L Tolman,Karen L MacNaul,Joel P Berger,Thomas W Doebber,Kwan Leung,David E Moller,James V Heck,Soumya P Sahoo

Bioorganic & Medicinal Chemistry Letters（2003）

引用 33|浏览25

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摘要

A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/db mouse type 2 diabetes animal model.

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