Homo and heterodimers of ddI, d4T and AZT: influence of (5'-5') thiolcabonate-carbamate linkage on anti-HIV activity.

M Taourirte,H B Lazrek,A Rochdi,J J Vasseur,J W Engels

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2005）

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摘要

New homo and heterodimers of ddI, d4T and AZT with (5'-5') thiolcarbonate-carbamate linkages have been prepared with the aim of testing them against wild type and NNRTI resistant HIV mutants. The prepared dimers showed a low activity in comparison to the parent drug.

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关键词

thiolcabonate-carbamate,anti-hiv

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