Outcome of Elderly Patients with Acute Lymphoblastic Leukemia (eall) with Chemotherapy: the Vancouver Experience

A. Tantiworawit,M. J. Barnett,D. L. Forrest,D. E. Hogge,S. H. Nantel,S. Narayanan,T. J. Nevill,M. M. Power,J. D. Shepherd,C. A. Smith,K. W. Song,H. J. Sutherland,C. L. Toze,Y. R. Abou Mourad

Biology of blood and marrow transplantation（2010）

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摘要

Age remains probably the most important prognostic factor in acute lymphoblastic leukemia (ALL). Adults with ALL have poor outcome with chemotherapy when compared to children; as age increases overall survival (OS) continuously declines. Elderly ALL (EALL) patients (pts) have the worst outcome with chemotherapy. Despite good initial response to induction chemotherapy, relapse rate (RR) is high and most pts will succumb to their disease. Few studies have addressed the outcome of EALL with chemotherapy.

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