3‘-Aminoadenosine-5‘-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A₃Receptor

Michael P. DeNinno,Hiroko Masamune,Lois K. Chenard,Kenneth J. DiRico,Cynthia Eller,John B. Etienne,Jeanene E. Tickner,Scott P. Kennedy,Delvin R. Knight, James W Kong,Joseph J. Oleynek,W. Ross Tracey,Roger J. Hill

JOURNAL OF MEDICINAL CHEMISTRY（2003）

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摘要

Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.

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3‘-Aminoadenosine-5‘-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A3Receptor

3‘-Aminoadenosine-5‘-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A₃Receptor